Article

Restoration of β-GC trafficking improves the lysosome function in Gaucher’s disease

2022-06-25

Abstract excerpt

Lysosomes function as a primary site for catabolism and cellular signaling. These organelles digest a variety of substrates received through endocytosis, secretion and autophagy with the help of resident acid hydrolases. Lysosomal enzymes are folded in the endoplasmic reticulum (ER) and trafficked to lysosomes via Golgi and endocytic route. The inability of hydrolase trafficking due to mutations or mutations in it...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fd6d5792-79fd-5aee-8e4f-7ef25250d720
DOI: 10.1101/2022.06.23.497394

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Restoration of β-GC trafficking improves the lysosome function in Gaucher’s diseaseDOI 10.1101/2022.06.23.497394Read

Lysosomal functions and dysfunctions: Molecular and cellular mechanisms underlying Gaucher disease and its association with Parkinson disease.Semantic proximity Read

A genome-wide screen identifies that PLCG2 restrains lysosomal GCase activity.Semantic proximity Read

Dysregulation of the autophagic-lysosomal pathway in Gaucher and Parkinson's diseaseSemantic proximity Read

New Directions in Gaucher Disease.Semantic proximity Read

Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease.Semantic proximity Read

Gaucher disease: a lysosomal neurodegenerative disorder.Semantic proximity Read

Lysosomal dysfunction in α-synuclein pathology: molecular mechanisms and therapeutic strategies.Semantic proximity Read

Fibroblasts from idiopathic Parkinson’s disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2Semantic proximity Read

Gaucher disease: Perspectives on a prototype lysosomal disease.Semantic proximity Read

Molecular regulations and therapeutic targets of Gaucher disease.Semantic proximity Read

Mitochondrial dysfunction associated with glucocerebrosidase deficiencySemantic proximity Read

[Pathogenic mechanism and therapies for Gaucher's disease].Semantic proximity Read