Article

SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells

2020-12-04

Abstract excerpt

The physiological functions of many vital tissues and organs continue to mature after birth, but the genetic mechanisms governing this postnatal maturation remain an unsolved mystery. Human pancreatic β-cells produce and secrete insulin in response to physiological cues like glucose, and these hallmark functions improve in the years after birth. This coincides with expression of the transcription factors SIX2 and...

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Literature Corpus work: 400bb118-cb90-53d4-b335-9c78a8da5eea
DOI: 10.1101/2020.12.03.411033

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