Article

Cholesterol-associated Locus <i>EHBP1</i> Protects against NASH Fibrosis

2023-07-10

Abstract excerpt

<h4>SUMMARY</h4> Hepatic free cholesterol contributes to fibrosis in nonalcoholic steatohepatitis (NASH), but how hepatic cholesterol metabolism becomes dysregulated in NASH is not completely understood. We show here that human fibrotic NASH livers have decreased EHBP1 , a novel GWAS locus associated with LDL-cholesterol, and that the EHBP1 rs10496099 T>C variant in NASH patients is associated with decreased he...

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Identifiers and source

Literature Corpus work: 51cc430c-f272-5c12-a276-77caf3cfa281
DOI: 10.1101/2023.07.08.548218

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