Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey.

Pharmacological research - 1 Nov 2016

Madasu Manish K, Okine Bright N, Olango Weredeselam M, Rea Kieran, Lenihan Róisín, Roche Michelle, Finn David P

Abstract excerpt

Negative affective state has a significant impact on pain, and genetic background is an important moderating influence on this interaction. The Wistar-Kyoto (WKY) inbred rat strain exhibits a stress-hyperresponsive, anxiety/depressive-like phenotype and also displays a hyperalgesic response to noxious stimuli. Transient receptor potential subfamily V member 1 (TRPV1) within the midbrain periaqueductal grey (PAG)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety
Share to Capsaicin
Share to Depression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diterpenes

Share to Rats, Inbred WKY

Share to Rats, Sprague-Dawley

Share to TRPV Cation Channels

Source

Identifiers

PMID: 27520401
DOI: 10.1016/j.phrs.2016.08.011

Genes

TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey.PMID 27520401Read ↗

Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia.Semantic proximity Read ↗

Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains.Semantic proximity Read ↗

Strain‐dependent variations in visceral sensitivity: relationship to stress, anxiety and spinal glutamate transporter expressionSemantic proximity Read ↗

Exacerbated mechanical hyperalgesia in rats with genetically predisposed depressive behavior: role of melatonin and NMDA receptors.Semantic proximity Read ↗

A genetically-defined population in the lateral and ventrolateral periaqueductal gray selectively promotes flight to safetySemantic proximity Read ↗

Genetic diversity contributes to abnormalities in pain behaviors between young and old rats.Semantic proximity Read ↗

Importance of epigenetic mechanisms in visceral pain induced by chronic water avoidance stressSemantic proximity Read ↗

The effect of genotype on sensitivity to inflammatory nociception: characterization of resistant (A/J) and sensitive (C57BL/6J) inbred mouse strains.Semantic proximity Read ↗

Brain region-specific expression of genes mapped within quantitative trait loci for behavioral responsiveness to acute stress in Fisher 344 and Wistar Kyoto male rats.Semantic proximity Read ↗

Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesiaSemantic proximity Read ↗

Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction.Semantic proximity Read ↗

Sex Differences in Visceral Pain and Comorbidities: Clinical Outcomes, Preclinical Models, and Cellular and Molecular MechanismsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.