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Article

A leptin-mediated central mechanism in analgesia-enhanced opioid reward in rats.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 Jul 2014

Lim Grewo, Kim Hyangin, McCabe Michael F, Chou Chiu-Wen, Wang Shuxing, Chen Lucy L, Marota John J A, Blood Anne, Breiter Hans C, Mao Jianren

Abstract excerpt

Opioid analgesics are commonly used in chronic pain management despite a potential risk of rewarding. However, it remains unclear whether opioid analgesia would enhance the opioid rewarding effect thereby contributing to opioid rewarding. Utilizing a rat paradigm of conditioned place preference (CPP) combined with ankle monoarthritis as a condition of persistent nociception, we showed that analgesia induced by...

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Share to Analgesics, Opioid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25031415
DOI: 10.1523/JNEUROSCI.0386-14.2014
PMCID: PMC4099551

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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