Article

Patient-specific iPSCs carrying an <i>SFTPC</i> mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease

2020-11-14

Abstract excerpt

<h4>Summary</h4> The incompletely understood pathogenesis of pulmonary fibrosis (PF) and lack of reliable preclinical disease models have limited development of effective therapies. An emerging literature now implicates alveolar epithelial type 2 cell (AEC2) dysfunction as an initiating pathogenic event in the onset of a variety of PF syndromes, including adult idiopathic pulmonary fibrosis (IPF) and childhood in...

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Literature Corpus work: 08aa8369-c6fe-5710-88c1-30aedf2cd9b7
DOI: 10.1101/2020.11.13.382390

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