Article

Suppression of de novo lipogenesis and dietary PUFA supplementation inhibit prostate cancer progression

2026-03-27

Abstract excerpt

Prostate cancer progression is characterized by dysregulated lipid metabolism, with fatty acid synthase (FASN), the rate-limiting step in de novo lipogenesis (DNL), resulting in significant accumulation of saturated lipids. Here, we investigate whether pharmacologic FASN inhibition creates a metabolic state that increases reliance on exogenous polyunsaturated fatty acids (PUFAs). Inhibition of FASN profoundly alt...

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Literature Corpus work: 3fcbd88f-8f34-55c3-80d0-b1c9cb180050
DOI: 10.64898/2026.03.25.714193

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