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Article

CpG Methylation Controls Reactivation of HIV from Latency

20 Aug 2009

Abstract excerpt

DNA methylation of retroviral promoters and enhancers localized in the provirus 5' long terminal repeat (LTR) is considered to be a mechanism of transcriptional suppression that allows retroviruses to evade host immune responses and antiretroviral drugs. However, the role of DNA methylation in the control of HIV-1 latency has never been unambiguously demonstrated, in contrast to the apparent importance of...

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PMID: 19696893
DOI: 10.1371/journal.ppat.1000554

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