Article

Functionalized Mesoporous Silicas Direct Structural Polymorphism of Amyloid-β Fibrils

2020-01-14

Abstract excerpt

The aggregation of Amyloid-β (Aβ) is associated with the onset of Alzheimer’s Disease (AD) and involves a complex kinetic pathway as monomers self-assemble into fibrils. A central feature of amyloid fibrils is the existence of multiple structural polymorphs, which complicates the development of disease-relevant structure-function relationships. Developing these relationships requires new methods to control fibril...

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Literature Corpus work: 3fb05b24-e37a-59b3-a364-b587e67fbcfa
DOI: 10.1101/2020.01.13.904854

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