Article
STK11 Mutations and Deletions Define an Aggressive Molecular Subgroup of Cervical Adenocarcinoma.
Cancer medicine - 1 Sept 2026
Robinson Emma W, Murphy Elisabeth A, Albanez Anaseidy, Tulsyan Sonam, Lou Hong, Xie Yi, Zhou Weiyin, Yang Qian, Joe Tawnjerae, Zhang Tongwu, Liu Jia, Luo Wen, Wu Dongjing, Higson Herbert, Viard Mathias, Carrington Mary, Oberley Matthew, Morales Hesler, Mirabello Lisa, Alvirez Enrique, Orozco Roberto, Gharzouzi Eduardo, Dean Michael
Abstract excerpt
Cervical adenocarcinoma accounts for 15%-20% of cervical cancers and is associated with poorer survival and reduced response to screening and immunotherapy compared with squamous cell carcinoma (SCC). The genomic drivers underlying this molecular subgroup remain incompletely characterized. Whole-exome sequencing was performed on 302 invasive cervical cancers from Guatemala and Venezuela. Structural variation...
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- Humans
- Female
- Uterine Cervical Neoplasms
- Adenocarcinoma
- AMP-Activated Protein Kinase Kinases