Article

Phase-separated stress granules and processing bodies are compromised in Myotonic Dystrophy Type 1

2021-06-15

Abstract excerpt

<h4>Summary</h4> RNA regulation in mammalian cells requires complex physical compartmentalisation using structures thought to be formed by liquid-liquid phase separation. Disruption of these structures is implicated in numerous degenerative diseases. Myotonic Dystrophy Type 1 (DM1) is a multi-systemic trinucleotide repeat disorder resulting from a CTG expansion in the dystonia myotonica protein kinase gene (DMPK)...

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Literature Corpus work: 3f9a9275-dd04-525c-8ccc-f840196cc8f0
DOI: 10.1101/2021.06.14.448303

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