Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs.

doi:10.1038/s41591-020-1087-x

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Article

Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs.

Nature medicine - 1 Nov 2020

Schneider Jay W, Oommen Saji, Qureshi Muhammad Y, Goetsch Sean C, Pease David R, Sundsbak Rhianna S, Guo Wei, Sun Mingming, Sun Han, Kuroyanagi Hidehito, Webster Dennis A, Coutts Alexander W, Holst Kimberly A, Edwards Brooks S, Newville Nikolas, Hathcock Matthew A, Melkamu Tamene, Briganti Francesca, Wei Wu, Romanelli Maria G, Fahrenkrug Scott C, Frantz Doug E, Olson Timothy M, Steinmetz Lars M, Carlson Daniel F, Nelson Timothy J

Abstract excerpt

Ribonucleoprotein (RNP) granules are biomolecular condensates-liquid-liquid phase-separated droplets that organize and manage messenger RNA metabolism, cell signaling, biopolymer assembly, biochemical reactions and stress granule responses to cellular adversity. Dysregulated RNP granules drive neuromuscular degenerative disease but have not previously been linked to heart failure. By exploring the molecular basis...

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Identifiers

PMID: 33188278
DOI: 10.1038/s41591-020-1087-x
PMCID: PMC9270981

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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