Transcriptional abnormality in myotonic dystrophy affects DMPK but not neighboring genes

doi:10.1073/pnas.94.14.7394

Article

Transcriptional abnormality in myotonic dystrophy affects DMPK but not neighboring genes

8 Jul 1997

Abstract excerpt

Myotonic dystrophy (DM) is caused by the expansion of a trinucleotide repeat, CTG, in the 3' untranslated region of a protein kinase gene, DMPK. We set out to determine what effect this expanded repeat has on RNA processing. The subcellular fractionation of RNA and the separate analysis of DMPK transcripts from each allele reveals that transcripts from expanded DMPK alleles are retained within the nucleus and are...

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