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Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency

17 Mar 2022

Abstract excerpt

Gpr125 is an orphan G-protein coupled receptor, with homology to cell adhesion and axonal guidance factors, that is implicated in planar polarity and control of cell movements. By lineage tracing we demonstrate that Gpr125 is a highly specific marker of bipotent mammary stem cells in the embryo and of multiple long-lived unipotent basal mammary progenitors in perinatal and postnatal glands. Nipple-proximal...

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PMID: 35302059
DOI: 10.1038/s41467-022-28937-x

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