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Article

Maternal high-fat diet induces hyperproliferation and alters Pten/Akt signaling in prostates of offspring

10 Dec 2013

Abstract excerpt

Developing recommendations for prostate cancer prevention requires identification of modifiable risk factors. Maternal exposure to high-fat diet (HFD) initiates a broad array of second-generation adult disorders in murine models and humans. Here, we investigate whether maternal HFD in mice affects incidence of prostate hyperplasia in offspring. Using three independent assays, we demonstrate that maternal HFD is...

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PMID: 24322661
DOI: 10.1038/srep03466

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