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Article

Extracellular Vesicle-Mediated Modulation of Stem-like Phenotype in Breast Cancer Cells under Fluid Shear Stress.

Biomolecules - 25 Jun 2024

Brown Spenser R, Radcliffe Margaret E, Danner Joseph T, Andújar Cruz Wilmer J, Lackey Kimberly H, Park Han-A, Weinman Steven T, Kim Yonghyun

Abstract excerpt

Circulating tumor cells (CTCs) are some of the key culprits that cause cancer metastasis and metastasis-related deaths. These cells exist in a dynamic microenvironment where they experience fluid shear stress (FSS), and the CTCs that survive FSS are considered to be highly metastatic and stem cell-like. Biophysical stresses such as FSS are also known to cause the production of extracellular vesicles (EVs) that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39062471
DOI: 10.3390/biom14070757
PMCID: PMC11274421

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CD24
CD44
MB

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