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Article

Multiscale agent-based modelling of ovarian cancer progression under the stimulation of the STAT 3 pathway.

International journal of data mining and bioinformatics - 1 Jan 2014

Zhang Le, Xue Yao, Jiang Beini, Strouthos Costas, Duan Zhenfeng, Wu Yukun, Su Jing, Zhou Xiaobo

Abstract excerpt

This research is developed to simulate ovarian cancer progression with signal transducers and activators of the transcription 3 (STAT 3) pathway. The main focus is on studying how the STAT 3 pathway affects the cancer cells' biomechanical phenotype under the stimulation of the interleukin-6 (IL-6) cytokine and various well-known microscopic factors. The simulated results agreed with recent experimental evidence...

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Identifiers

PMID: 25163167
DOI: 10.1504/ijdmb.2014.060050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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