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Genetic polymorphisms in SLCO2B1 and ABCC1 conjointly modulate atorvastatin intracellular accumulation in HEK293 recombinant cell lines

2022-04-27

Abstract excerpt

Atorvastatin (ATV), is commonly used to treat hypercholesterolemia. Although generally well tolerated, patients can suffer from muscle complaints and the occurrence of this discomfort is difficult to predict. Muscle side effects are assumed to be linked to the intramuscular ATV accumulation. The aim of our study was to investigate the relative implication of influx and efflux transporters expressed in the muscle t...

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Literature Corpus work
3f1efb4a-8bf4-512f-9415-70f7a4a40f12
DOI
10.21203/rs.3.rs-1520877/v1
Open publication

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Genetic polymorphisms in SLCO2B1 and ABCC1 conjointly modulate atorvastatin intracellular accumulation in HEK293 recombinant cell linesDOI 10.21203/rs.3.rs-1520877/v1
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