Article
The atorvastatin metabolic phenotype shift is influenced by interaction of drug-transporter polymorphisms in Mexican population: results of a randomized trial.
Scientific reports - 1 Jun 2020
León-Cachón Rafael B R, Bamford Aileen-Diane, Meester Irene, Barrera-Saldaña Hugo Alberto, Gómez-Silva Magdalena, Bustos María F García
Abstract excerpt
Atorvastatin (ATV) is a blood cholesterol-lowering drug used to prevent cardiovascular events, the leading cause of death worldwide. As pharmacokinetics, metabolism and response vary among individuals, we wanted to determine the most reliable metabolic ATV phenotypes and identify novel and preponderant genetic markers that affect ATV plasma levels. A controlled, randomized, crossover, single-blind,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.