Article

TAF1-dependent transcriptional dysregulation underlies multiple sclerosis

2024-08-25

Abstract excerpt

A major conceptual and clinical challenge in multiple sclerosis (MS) is understanding the mechanisms that drive the central nervous system (CNS)-resident neuroinflammation and neurodegeneration underneath disease progression. Genome-wide association studies (GWAS) have implicated RNA polymerase II (RNAPII) promoter-proximal pausing in oligodendrocyte pathology, but the causal mechanisms remain unclear. Here we fin...

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Literature Corpus work: 3f0a38ce-c358-5c94-9884-1eb57e13a067
DOI: 10.1101/2024.08.23.609325

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