Article
Gene Expression and Alternative Splicing Analysis in a Large-Scale Multiple Sclerosis Study.
International journal of molecular sciences - 7 Nov 2024
Sak Müge, Chariker Julia H, Park Juw Won, Rouchka Eric Christian
Abstract excerpt
Multiple Sclerosis (MS) is an autoimmune neurodegenerative disease affecting approximately 3 million people globally. Despite rigorous research on MS, aspects of its development and progression remain unclear. We utilized a publicly available RNA-seq dataset (GSE138614) consisting of the post-mortem white matter tissues of five donors without any neurological disorders and ten MS patient donors. We investigated...
Topics
- Humans
- Alternative Splicing
- Multiple Sclerosis
- Polymorphism, Single Nucleotide
- White Matter
- RNA-Binding Proteins
- Female
- Gene Expression Profiling
- Male
- Gene Expression Regulation