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Article

Mutational landscape changes of AML in patients relapsing after allogeneic hematopoietic cell transplantation.

Bone marrow transplantation - 1 Jun 2026

Maas-Bauer Kristina, Meyer Thomas, Yücel Mehtap, Garofalaki Maria, Koßmann Stefanie, Biavasco Francesca, Lysandrou Memnon, Waterhouse Miguel, Feuchtinger Tobias, Pfeifer Dietmar, Ingelfinger Florian, Wertheimer Tobias, Duyster Justus, Ahn Jae Sook, Soiffer Robert J, Finke Jürgen, Wäsch Ralph, Spyridonidis Alexandros, Kim Dennis Dong Hwan, Wehr Claudia, Zeiser Robert

Abstract excerpt

Relapse of acute myeloid leukemia (AML) following allogeneic hematopoietic cell transplantation (allo-HCT) remains a life-threatening complication and is influenced by the underlying biology of the AML and possibly by genetic alterations. In this retrospective multicenter study, we evaluated mutational dynamics of AML cells in 57 patients with relapse after allo-HCT. We observed that 68% of patients exhibited...

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Identifiers

PMID: 41933230
DOI: 10.1038/s41409-026-02813-4
PMCID: PMC13241310

Genes

DNMT3A
FLT3
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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