Clonal evolution including partial loss of human leukocyte antigen genes favoring extramedullary acute myeloid leukemia relapse after matched related allogeneic hematopoietic stem cell transplantation.

doi:10.1097/TP.0b013e3182481113

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Article

Clonal evolution including partial loss of human leukocyte antigen genes favoring extramedullary acute myeloid leukemia relapse after matched related allogeneic hematopoietic stem cell transplantation.

Transplantation - 15 Apr 2012

Stölzel Friedrich, Hackmann Karl, Kuithan Friederike, Mohr Brigitte, Füssel Monika, Oelschlägel Uta, Thiede Christian, Röllig Christoph, Platzbecker Uwe, Schetelig Johannes, Illmer Thomas, Schaich Markus, Seliger Barbara, Hartmann Arndt, Baretton Gustavo, Zietz Christian, Ehninger Gerhard, Schrock Evelin, Bornhäuser Martin

Abstract excerpt

BACKGROUND: Relapse of acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (HSCT) leaves few therapeutic options, and mechanisms of immune escape of recurring leukemic cells remain poorly understood. Recently, acquired loss of mismatched human leukocyte antigen (HLA) was demonstrated in patients with AML undergoing haploidentical allogeneic HSCT and was suggested not to occur in...

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PMID: 22314337
DOI: 10.1097/TP.0b013e3182481113

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TAP2

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