Article

An activating mutation in AGEF-1, a putative Arf GEF, causes yolk extrusion from <i>C. elegans</i> embryos

2026-02-11

Abstract excerpt

C. elegans AGEF-1, an ortholog of human ARFGEF1 and ARFGEF2, functions with ARF-1, ARF-5 and the AP-1 clathrin adaptor to regulate membrane trafficking. Similar phenotypes induced by the agef-1(vh4[E1028K]) allele and agef-1(RNAi) suggested that agef-1(vh4) was a hypomorph. Here we report that agef-1(vh4) results in extrusion of yolk from the embryo. This is suppressed by RNAi of agef-1, arf-1, arf-5 but not...

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Literature Corpus work: 3ef448b7-b221-5056-a901-1188e192dcee
DOI: 10.64898/2026.02.10.705107

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