Article
Repression of cell-cell fusion by components of the C. elegans vacuolar ATPase complex.
Developmental cell - 1 May 2005
Kontani Kenji, Moskowitz Ivan P G, Rothman Joel H
Abstract excerpt
Cell-cell fusion initiates fertilization, sculpts tissues during animal development, reprograms stem cells to new differentiated states, and may be a key step in cancer progression. While cell fusion is tightly regulated, the mechanisms that limit fusion to appropriate partners are unknown. Here, we report that the fus-1 gene is essential to repress fusion of epidermal cells in C. elegans: in severe fus-1...
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