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A Dual-Function Guanidinium Scaffold that Couples Copper Sequestration with Redox Protection in Wilson disease

2026-06-15

Abstract excerpt

Wilson disease (WD) is caused due to mutations in the copper ATPase gene ATP7B, that result in accumulation of labile copper pools and the consequent disruption of cellular redox homeostasis through uncontrolled copper-mediated reactive oxygen species generation. Current therapies mainly depend on high-affinity copper chelation to lower metal burden which sometimes also strip copper from cuproproteins and may dist...

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Literature Corpus work
32e00457-114f-5b0d-b46e-9c68018db125
DOI
10.64898/2026.06.11.731572
Open publication

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A Dual-Function Guanidinium Scaffold that Couples Copper Sequestration with Redox Protection in Wilson diseaseDOI 10.64898/2026.06.11.731572
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