Article

Repurposing Melatonin in dual-mode for Wilson disease therapy as a Copper Chelator and an antioxidant agent

2025-09-02

Abstract excerpt

Loss-of-function mutations in copper-ATPase ATP7B underlie Wilson disease (WD), a disorder characterized by hepatic copper accumulation and severe hepato-neuropathology. Existing chelation therapeutics remove excess copper but lack intrinsic antioxidant capacity and frequently cause systemic toxicity. Here we evaluate melatonin, an FDA-approved indoleamine with antioxidant and putative metal-chelating activity, as...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1d884697-5a9a-5d1b-bd61-d11aff86cc5f
DOI: 10.1101/2025.08.30.673002

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Repurposing Melatonin in dual-mode for Wilson disease therapy as a Copper Chelator and an antioxidant agentDOI 10.1101/2025.08.30.673002Read

A Dual-Function Guanidinium Scaffold that Couples Copper Sequestration with Redox Protection in Wilson diseaseSemantic proximity Read

Cuproplasia and cuproptosis, two sides of the coinSemantic proximity Read

Copper-containing ROS-scavenging nanozyme paradoxically drives α-synucleinopathy by amplifying nitrosative stressSemantic proximity Read

ZNT1 involves cuproptosis through regulating MTF1-conduced expression of MT1X under copper overloadSemantic proximity Read

Copper-induced suppression of the PPARα–FABP1 axis sensitizes hepatocytes to ferroptosis in Wilson diseaseSemantic proximity Read

Discovery of a druggable copper-signaling pathway that drives cell plasticity and inflammationSemantic proximity Read

Metallothionein Is Inappropriate to Neutralise Excess Hepatic Copper in Wilson’s DiseaseSemantic proximity Read

Rosmarinic acid ameliorated oxidative stress, neuronal injuries, and mitochondrial dysfunctions mediated by polyglutamine and ɑ-synuclein in Caenorhabditis elegans modelsSemantic proximity Read

The synucleins are a family of redox-active copper binding proteins.Semantic proximity Read

JWA binding to NCOA4 alleviates degeneration in dopaminergic neurons through suppression of ferritinophagy in Parkinson's diseaseSemantic proximity Read

Liver mitochondrial membrane crosslinking and destruction in a rat model of Wilson diseaseSemantic proximity Read

Cuproptosis: a copper-triggered modality of mitochondrial cell deathSemantic proximity Read