Article

Single-Cell Mapping of tRNA Expression Dynamics Across Human Hematopoiesis

2026-08-15

Abstract excerpt

How transfer RNA (tRNA) expression changes as hematopoietic stem cells are specified into human blood cell types remains unknown. tRNAs translate the 64-codon genetic code into the 21-amino acid protein code, and their relative abundance can influence proteomic output. Here, we introduce simultaneous single-cell tRNA and mRNA sequencing (sc-STM-seq), a scalable, high-throughput approach for profiling tRNAs alongsi...

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Literature Corpus work: 3ec918c7-b558-5a74-8a37-3fc830f704de
DOI: 10.64898/2026.08.14.744819

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