Article
Proto-genes and de novo gene birth.
Nature - 19 Jul 2012
Carvunis Anne-Ruxandra, Rolland Thomas, Wapinski Ilan, Calderwood Michael A, Yildirim Muhammed A, Simonis Nicolas, Charloteaux Benoit, Hidalgo César A, Barbette Justin, Santhanam Balaji, Brar Gloria A, Weissman Jonathan S, Regev Aviv, Thierry-Mieg Nicolas, Cusick Michael E, Vidal Marc
Abstract excerpt
Novel protein-coding genes can arise either through re-organization of pre-existing genes or de novo. Processes involving re-organization of pre-existing genes, notably after gene duplication, have been extensively described. In contrast, de novo gene birth remains poorly understood, mainly because translation of sequences devoid of genes, or 'non-genic' sequences, is expected to produce insignificant...
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