Article

Automated protein-protein structure prediction of the T cell receptor-peptide major histocompatibility complex

2022-06-01

Abstract excerpt

<h4>ABSTRACT</h4> T Cell Receptor (TCR) recognition of a peptide-major histocompatibility complex (pMHC) is a crucial component of the adaptive immune response. The identification of therapeutically relevant TCR-pMHC pairs is a significant bottleneck in the implementation of TCR-based immunotherapies but may be augmented by computational methodologies. The ability to computationally design TCRs to target a specif...

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Literature Corpus work: 3ec531ab-9bf0-54b5-9b17-a2c97b1e86d1
DOI: 10.1101/2022.06.01.494331

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