Article

Characterization of a Novel MAP4K4-SASH1 Kinase Cascade Regulating Breast Cancer Tumorigenesis and Metastasis

2020-11-05

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: The SAM and SH3 domain containing protein 1(SASH1) was previously described as a candidate tumor-suppressor gene in breast cancer and colon cancer to mediate tumor metastasis and tumor growth. However，the underlying mechanisms by which SASH1 implements breast cancer tumorigenesis and the question why SASH1 is downregulated in most solid cancers remain unexplored...

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Literature Corpus work: 3ebde878-4fa4-5862-ab34-652adfbaa5e1
DOI: 10.21203/rs.3.rs-101160/v1

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