BRIT1 Inhibits Invasion and Metastasis by Regulating SERPINA5 in Hepatocellular Carcinoma

Abstract excerpt

<title>Abstract</title> <p><bold>Purpose</bold>: BRIT1 (also known as MCPH1) is a DNA repair and tumor suppressor gene, whose alterations might be potentially associated with tumor progression and metastasis in HCC. SERPINA5, also known as Protein C inhibitor, has been reported to be decreased in a variety of human cancers and its decrease is associated with cellular invasion and tumor metastasis. However, little...

Topics

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• Calpain Protease Function and Regulation
• Cancer, Lipids, and Metabolism
• Ferroptosis and cancer prognosis
• Peptidase Inhibition and Analysis
• Protease and Inhibitor Mechanisms
• Signaling Pathways in Disease

Identifiers and source

Literature Corpus work

8f7cec14-db98-5dcc-ba26-1d6f8deeee71

DOI

10.21203/rs.3.rs-531030/v1