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Article

Persistent androgen receptor addiction in castration-resistant prostate cancer

13 Nov 2015

Abstract excerpt

It is now understood that persistent activation of the androgen receptor (AR) signaling pathway often underlies the development of castration-resistant prostate cancer (CRPC). This realization led to renewed interest in targeting the AR and ultimately to the development of the potent next-generation AR-directed agents abiraterone and enzalutamide. While these drugs prolong survival in men with CRPC, they are...

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Share to Estrogen and related hormone effects
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PMID: 26566796
DOI: 10.1186/s13045-015-0225-2

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