Article
Spectral analysis by XANES reveals that GPNMB influences the chemical composition of intact melanosomes.
Pigment cell & melanoma research - 1 Feb 2011
Haraszti Tamás, Trantow Colleen M, Hedberg-Buenz Adam, Grunze Michael, Anderson Michael G
Abstract excerpt
GPNMB is a unique melanosomal protein. Unlike many melanosomal proteins, GPNMB has not been associated with any forms of albinism, and it is unclear whether GPNMB has any direct influence on melanosomes. Here, melanosomes from congenic strains of C57BL/6J mice mutant for Gpnmb are compared to strain-matched controls using standard transmission electron microscopy and synchrotron-based X-ray absorption near-edge...
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