Article

Liver transplant rejection features memory cell priming, spatially differentiated networks and novel drug targets

2025-02-07

Abstract excerpt

Acute T-cell-mediated transplant rejection, the earliest contributor to immunological graft failure responds variably to T-cell suppression. Early rejection can co-exist with donor-specific antibodies which also shorten graft survival, without affecting graft histology visibly. Here, during early liver transplant rejection, blood leukocytes manifest primed T-cells with heat shock protein (HSP) signaling and transc...

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Literature Corpus work: 3e82f099-e50d-524c-ba5f-96dbce1e9616
DOI: 10.1101/2025.02.04.635308

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