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Liver-resident CD8+ T cells in viral hepatitis: not always good guys

2 Jan 2023

Abstract excerpt

More than twenty years ago, non-HBV-specific CD8+ T cells were found to contribute to liver immunopathology in chronic HBV infection, while HBV-specific CD8+ T cells were noted to contribute to viral control. The role of HBV-specific CD8+ T cells in viral control and the mechanisms of their failure in persistent infection have been intensively studied during the last two decades, but the exact nature of...

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PMID: 36594469
DOI: 10.1172/jci165033

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