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Mechanisms of Hepatocellular Injury in Hepatitis A

8 May 2021

Abstract excerpt

Hepatitis A virus (HAV) infection is a common cause of acute viral hepatitis worldwide. Despite decades of research, the pathogenic mechanisms of hepatitis A remain incompletely understood. As the replication of HAV is noncytopathic in vitro, a widely accepted concept has been that virus-specific cytotoxic T cells are responsible for liver injury. However, accumulating evidence suggests that natural killer (NK)...

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PMID: 34066709
DOI: 10.3390/v13050861

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