Article

Vaccine induction of CD4-mimicking broadly neutralizing antibody precursors in macaques

2023-03-05

Abstract excerpt

<h4>SUMMARY</h4> The CD4 binding site (CD4bs) is a conserved epitope on HIV-1 envelope (Env) that can be targeted by protective broadly neutralizing antibodies (bnAbs). HIV-1 vaccines have not elicited CD4bs bnAbs for many reasons, including the CD4bs is occluded by glycans, immunogen expansion of appropriate naïve B cells, and selection of functional antibody mutations. Here, we demonstrate immunization of macaq...

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Literature Corpus work: 3da13033-2f5d-5a82-bffe-a6c81af955dc
DOI: 10.1101/2023.03.05.531154

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