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Article

Genetic contributions to avoidance-based decisions: striatal D2 receptor polymorphisms.

Neuroscience - 24 Nov 2009

Frank M J, Hutchison K

Abstract excerpt

Individuals differ in their tendencies to seek positive decision outcomes or to avoid negative ones. At the neurobiological level, our model suggests that phasic changes in dopamine support learning to reinforce good decisions via striatal D1 receptors, and to avoid maladaptive choices via striatal D2 receptors. Accordingly, in a previous study individual differences in positive and negative learning were...

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Share to Decision Making
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19393722
DOI: 10.1016/j.neuroscience.2009.04.048
PMCID: PMC2760598

Genes

DRD2

Variants

rs6277

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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