Article

The VPS35 p.A320V variant segregates with Parkinson's disease in a pesticide-exposed family

2026-08-24

Abstract excerpt

<h4>Background: </h4> The VPS35 p.D620N variant causes autosomal dominant Parkinson's disease (PD) and has been shown to activate the LRRK2 kinase pathway, resulting in increased Rab substrate phosphorylation in peripheral immune cells and elevated urinary bis(monoacylglycero)phosphate (BMP) levels. Recently, a VPS35 variant of unknown significance (c.959C>T; p.A320V) was described in two late-onset sporadic PD pa...

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Literature Corpus work: 3d67c728-a6d8-50dd-94d7-76a0693ff3d1
DOI: 10.64898/2026.08.21.26358613

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