RAB32 Ser71Arg in autosomal dominant Parkinson's disease: linkage, association, and functional analyses.

doi:10.1016/S1474-4422(24)00121-2

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Article

RAB32 Ser71Arg in autosomal dominant Parkinson's disease: linkage, association, and functional analyses.

The Lancet. Neurology - 1 Jun 2024

Gustavsson Emil K, Follett Jordan, Trinh Joanne, Barodia Sandeep K, Real Raquel, Liu Zhiyong, Grant-Peters Melissa, Fox Jesse D, Appel-Cresswell Silke, Stoessl A Jon, Rajput Alex, Rajput Ali H, Auer Roland, Tilney Russel, Sturm Marc, Haack Tobias B, Lesage Suzanne, Tesson Christelle, Brice Alexis, Vilariño-Güell Carles, Ryten Mina, Goldberg Matthew S, West Andrew B, Hu Michele T, Morris Huw R, Sharma Manu, Gan-Or Ziv, Samanci Bedia, Lis Pawel, Periñan Maria Teresa, Amouri Rim, Ben Sassi Samia, Hentati Faycel, Tonelli Francesca, Alessi Dario R, Farrer Matthew J

Abstract excerpt

BACKGROUND: Parkinson's disease is a progressive neurodegenerative disorder with multifactorial causes, among which genetic risk factors play a part. The RAB GTPases are regulators and substrates of LRRK2, and variants in the LRRK2 gene are important risk factors for Parkinson's disease. We aimed to explore genetic variability in RAB GTPases within cases of familial Parkinson's disease. METHODS: We did...

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Identifiers

PMID: 38614108
DOI: 10.1016/S1474-4422(24)00121-2
PMCID: PMC11096864

Genes

RAB32
GP2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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