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Article

Novel variants in genes related to vesicle-mediated-transport modify Parkinson's disease risk.

Molecular genetics and metabolism - 1 Jun 2023

Goldstein Orly, Gana-Weisz Mali, Banfi Sandro, Nigro Vincenzo, Bar-Shira Anat, Thaler Avner, Gurevich Tanya, Mirelman Anat, Giladi Nir, Alcalay Roy N, Orr-Urtreger Avi

Abstract excerpt

OBJECTIVES: VPS35 and VPS13 have been associated with Parkinson's disease (PD), and their shared phenotype in yeast when reduced in function is abnormal vacuolar transport. We aim to test if additional potentially deleterious variants in other genes that share this phenotype can modify the risk for PD. METHODS: 77 VPS and VPS-related genes were analyzed using whole-genome-sequencing data from 202 PD patients of...

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PMID: 37201419
DOI: 10.1016/j.ymgme.2023.107608

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