Article

Identification of Juglone, a ‘first-in-class’ inhibitor of the human glutathione degrading enzyme, ChaC1, using yeast-based high throughput screens

2024-07-22

Abstract excerpt

The cytosolic glutathione-degrading enzyme, ChaC1, is highly upregulated in several cancers, with the upregulation correlating to poor prognosis. The ability to inhibit ChaC1 thus becomes important in pathophysiological situations where elevated glutathione levels would be beneficial. As no inhibitors of ChaC1 are known, in this study we have focussed on this goal. We have initially taken a computational approach...

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Literature Corpus work: 3d4693f4-3c7e-52ee-b29d-7decffd943fc
DOI: 10.1101/2024.07.21.604522

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