Article

Screening of small molecule chemical library identifies leads that reduce cholesterol accumulation in human NPC1 fibroblasts

2022-11-16

Abstract excerpt

Although considerable progress has been made in finding a therapy for Niemann-Pick type C1 (NPC1) disease, there still is no effective approved treatment. Previously, we reported results from a small molecule screen that was conducted on Chinese Hamster Ovary (CHO) cells (CT60) that lacked NPC1 expression. The hit compounds that were effective in reducing cholesterol accumulation in CT60 cells were not effective o...

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Literature Corpus work: 4633cc94-28e6-500b-8cca-bdac74c4f4b8
DOI: 10.1101/2022.11.16.516777

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