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Article

Structural and Functional Analyses of Human ChaC2 in Glutathione Metabolism.

Biomolecules - 24 Dec 2019

Nguyen Yen T K, Park Joon Sung, Jang Jun Young, Kim Kyung Rok, Vo Tam T L, Kim Kyu-Won, Han Byung Woo

Abstract excerpt

Glutathione (GSH) degradation plays an essential role in GSH homeostasis, which regulates cell survival, especially in cancer cells. Among human GSH degradation enzymes, the ChaC2 enzyme acts on GSH to form 5-l-oxoproline and Cys-Gly specifically in the cytosol. Here, we report the crystal structures of ChaC2 in two different conformations and compare the structural features with other known...

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Identifiers

PMID: 31878259
DOI: 10.3390/biom10010031
PMCID: PMC7022552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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