Article

RNF149 confers cisplatin resistance in esophageal squamous cell carcinoma via destabilization of PHLPP2 and activating PI3K/AKT signalling

2023-06-28

Abstract excerpt

<title>Abstract</title> <p>Chemo-resistance has been identified as a crucial factor contributing to tumor recurrence and a leading cause of worse prognosis in patients with ESCC. Therefore, unravel the critical regulators and effective strategies to overcome drug resistance will have a significant clinical impact on the disease. In our study we found that RNF149 was upregulated in ESCC and high RNF149 expression...

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Literature Corpus work: f629dcac-527c-5670-af57-b152f4d79015
DOI: 10.21203/rs.3.rs-3070542/v1

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