Article
NRAS destines tumor cells to the lungs.
EMBO molecular medicine - 1 May 2017
Giannou Anastasios D, Marazioti Antonia, Kanellakis Nikolaos I, Giopanou Ioanna, Lilis Ioannis, Zazara Dimitra E, Ntaliarda Giannoula, Kati Danai, Armenis Vasileios, Giotopoulou Georgia A, Krontira Anthi C, Lianou Marina, Agalioti Theodora, Vreka Malamati, Papageorgopoulou Maria, Fouzas Sotirios, Kardamakis Dimitrios, Psallidas Ioannis, Spella Magda, Stathopoulos Georgios T
Abstract excerpt
The lungs are frequently affected by cancer metastasis. Although NRAS mutations have been associated with metastatic potential, their exact role in lung homing is incompletely understood. We cross-examined the genotype of various tumor cells with their ability for automatic pulmonary dissemination, modulated NRAS expression using RNA interference and NRAS overexpression, identified NRAS signaling partners by...
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