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Article

The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity.

Development (Cambridge, England) - 1 Apr 2010

Tran Uyen, Zakin Lise, Schweickert Axel, Agrawal Raman, Döger Remziye, Blum Martin, De Robertis E M, Wessely Oliver

Abstract excerpt

The RNA-binding protein Bicaudal C is an important regulator of embryonic development in C. elegans, Drosophila and Xenopus. In mouse, bicaudal C (Bicc1) mutants are characterized by the formation of fluid-filled cysts in the kidney and by expansion of epithelial ducts in liver and pancreas. This phenotype is reminiscent of human forms of polycystic kidney disease (PKD). Here, we now provide data that Bicc1...

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Identifiers

PMID: 20215348
DOI: 10.1242/dev.046045
PMCID: PMC2835326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity.PMID 20215348Read ↗

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