Article
Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity.
Diabetes - 1 Feb 2017
Cianciaruso Chiara, Phelps Edward A, Pasquier Miriella, Hamelin Romain, Demurtas Davide, Alibashe Ahmed Mohamed, Piemonti Lorenzo, Hirosue Sachiko, Swartz Melody A, De Palma Michele, Hubbell Jeffrey A, Baekkeskov Steinunn
Abstract excerpt
The target autoantigens in several organ-specific autoimmune diseases, including type 1 diabetes (T1D), are intracellular membrane proteins, whose initial encounter with the immune system is poorly understood. Here we propose a new model for how these proteins can initiate autoimmunity. We found that rat and human pancreatic islets release the intracellular β-cell autoantigens in human T1D, GAD65, IA-2, and...
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