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Article

The ligand-dependent interaction of mineralocorticoid receptor with coactivator and corepressor peptides suggests multiple activation mechanisms.

Molecular endocrinology (Baltimore, Md.) - 1 Jun 2005

Hultman Monica L, Krasnoperova Nataliia V, Li Suzhen, Du Sarah, Xia Chunsheng, Dietz Jessica D, Lala Deepak S, Welsch Dean J, Hu Xiao

Abstract excerpt

We investigated the coregulator (coactivator and corepressor) interactions with the mineralocorticoid receptor (MR) that lead to activation and inhibition of the receptor in the presence of agonist and/or antagonist. Our results indicate that MR ligand binding domain (LBD) interacts strongly with only a few specific coactivator peptides in the presence of the agonist aldosterone and that these interactions are...

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Identifiers

PMID: 15761029
DOI: 10.1210/me.2004-0537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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